abstract：OBJECTIVES:The purpose of this study was to assess whether changes of major atrial fibrillation (AF) risk factors and/or intercurrent cardiovascular events could explain the relationship between type 2 diabetes mellitus (T2D) and incident AF. BACKGROUND:Previous studies found an increased risk of incident AF among ind...

journal_title：Journal of the American College of Cardiology

authors： Schoen T,Pradhan AD,Albert CM,Conen D

更新日期：2012-10-09 00:00:00

abstract：OBJECTIVES:This study sought to measure the impact of pre-hospital (PH) electrocardiography (ECG) on scene-to-hospital time for patients with chest pain of cardiac origin and those with ST-segment elevation myocardial infarction (STEMI). BACKGROUND:Pre-hospital ECG decreases door-to balloon (D2B) time for STEMI patien...

journal_title：Journal of the American College of Cardiology

authors： Patel M,Dunford JV,Aguilar S,Castillo E,Patel E,Fisher R,Ochs G,Mahmud E

更新日期：2012-08-28 00:00:00

abstract：OBJECTIVES:The purpose of this study is investigate the effects of variants in the apolipoprotein(a) gene (LPA) on vascular diseases with different atherosclerotic and thrombotic components. BACKGROUND:It is unclear whether the LPA variants rs10455872 and rs3798220, which correlate with lipoprotein(a) levels and coron...

journal_title：Journal of the American College of Cardiology

authors： Helgadottir A,Gretarsdottir S,Thorleifsson G,Holm H,Patel RS,Gudnason T,Jones GT,van Rij AM,Eapen DJ,Baas AF,Tregouet DA,Morange PE,Emmerich J,Lindblad B,Gottsäter A,Kiemeny LA,Lindholt JS,Sakalihasan N,Ferrell RE,C

更新日期：2012-08-21 00:00:00

abstract：OBJECTIVES:The purpose of this study was to demonstrate the feasibility and procedural outcomes with a new self-expanding and repositionable transcatheter heart valve. BACKGROUND:Transcatheter aortic valve replacement is a viable option for selected patients with severe symptomatic aortic stenosis. However, suboptimal...

journal_title：Journal of the American College of Cardiology

authors： Willson AB,Rodès-Cabau J,Wood DA,Leipsic J,Cheung A,Toggweiler S,Binder RK,Freeman M,DeLarochellière R,Moss R,Nombela-Franco L,Dumont E,Szummer K,Fontana GP,Makkar R,Webb JG

更新日期：2012-08-14 00:00:00

abstract：OBJECTIVES:This study sought to determine the range and prevalence of practices being implemented by hospitals to reduce 30-day readmissions of patients with heart failure or acute myocardial infarction (AMI). BACKGROUND:Readmissions of patients with heart failure or AMI are both common and costly; however, evidence o...

journal_title：Journal of the American College of Cardiology

authors： Bradley EH,Curry L,Horwitz LI,Sipsma H,Thompson JW,Elma M,Walsh MN,Krumholz HM

更新日期：2012-08-14 00:00:00

abstract：OBJECTIVES:This study tested the hypothesis that response to antiarrhythmic drugs (AADs) is modulated by 3 common loci associated with atrial fibrillation (AF). BACKGROUND:Recent genome-wide association studies have identified 3 loci, on chromosomes 4q25 (near PITX2), 16q22 (in ZFHX3), and 1q21 (in KCNN3), that associ...

journal_title：Journal of the American College of Cardiology

authors： Parvez B,Vaglio J,Rowan S,Muhammad R,Kucera G,Stubblefield T,Carter S,Roden D,Darbar D

更新日期：2012-08-07 00:00:00

abstract：OBJECTIVES:This study investigated the impact on recurrences of 2 different substrate approaches for the treatment of these arrhythmias. BACKGROUND:Catheter ablation of electrical storms (ES) for ventricular arrhythmias (VAs) has shown moderate long-term efficacy in patients with ischemic cardiomyopathy. METHODS:Nine...

journal_title：Journal of the American College of Cardiology

authors： Di Biase L,Santangeli P,Burkhardt DJ,Bai R,Mohanty P,Carbucicchio C,Dello Russo A,Casella M,Mohanty S,Pump A,Hongo R,Beheiry S,Pelargonio G,Santarelli P,Zucchetti M,Horton R,Sanchez JE,Elayi CS,Lakkireddy D,Tondo C

更新日期：2012-07-10 00:00:00

abstract：OBJECTIVES:The purpose of this study was to evaluate the feasibility, safety, and clinical outcomes up to 1 year in patients undergoing combined simultaneous thoracoscopic surgical and transvenous catheter atrial fibrillation (AF) ablation. BACKGROUND:The combination of the transvenous endocardial approach with the th...

journal_title：Journal of the American College of Cardiology

authors： Pison L,La Meir M,van Opstal J,Blaauw Y,Maessen J,Crijns HJ

更新日期：2012-07-03 00:00:00

abstract：OBJECTIVES:The authors investigated predictors of left ventricular ejection fraction (LVEF) super-response to cardiac resynchronization therapy with defibrillator (CRT-D) and whether super-response translated into improved event-free survival in patients with mildly symptomatic heart failure (HF). BACKGROUND:Few data ...

journal_title：Journal of the American College of Cardiology

authors： Hsu JC,Solomon SD,Bourgoun M,McNitt S,Goldenberg I,Klein H,Moss AJ,Foster E,MADIT-CRT Executive Committee.

更新日期：2012-06-19 00:00:00

abstract：OBJECTIVES:The purpose of this study was to analyze the electrophysiologic remodeling of the atrophic left ventricle (LV) in right ventricular (RV) failure (RVF) after RV pressure overload. BACKGROUND:The LV in pressure-induced RVF develops dysfunction, reduction in mass, and altered gene expression, due to atrophic r...

journal_title：Journal of the American College of Cardiology

authors： Hardziyenka M,Campian ME,Verkerk AO,Surie S,van Ginneken AC,Hakim S,Linnenbank AC,de Bruin-Bon HA,Beekman L,van der Plas MN,Remme CA,van Veen TA,Bresser P,de Bakker JM,Tan HL

更新日期：2012-06-12 00:00:00

abstract：OBJECTIVES:This study sought to investigate the efficacy, safety, and antiplatelet effect of prasugrel as compared with clopidogrel in patients with high on-treatment platelet reactivity (HTPR) after elective percutaneous coronary intervention (PCI). BACKGROUND:The extent to which prasugrel can correct HTPR and improv...

journal_title：Journal of the American College of Cardiology

authors： Trenk D,Stone GW,Gawaz M,Kastrati A,Angiolillo DJ,Müller U,Richardt G,Jakubowski JA,Neumann FJ

更新日期：2012-06-12 00:00:00

abstract：OBJECTIVES:This study was designed to compare the accuracy of 64-row contrast computed tomography (CT), invasive cineventriculography (CVG), 2-dimensional echocardiography (2D Echo), and 3-dimensional echocardiography (3D Echo) for left ventricular (LV) function assessment with magnetic resonance imaging (MRI). BACKGR...

journal_title：Journal of the American College of Cardiology

authors： Greupner J,Zimmermann E,Grohmann A,Dübel HP,Althoff TF,Borges AC,Rutsch W,Schlattmann P,Hamm B,Dewey M

更新日期：2012-05-22 00:00:00

abstract：:Ventricular arrhythmia (VA) in structurally normal hearts can be broadly considered under non-life-threatening monomorphic and life-threatening polymorphic rhythms. Monomorphic VA is classified on the basis of site of origin in the heart, and the most common areas are the ventricular outflow tracts and left ventricula...

journal_title：Journal of the American College of Cardiology

authors： Prystowsky EN,Padanilam BJ,Joshi S,Fogel RI

更新日期：2012-05-15 00:00:00

abstract：OBJECTIVES:In this study, our goal was to determine if human resistin plays a role in regulating the uptake of atherogenic low-density lipoproteins in human hepatocytes. BACKGROUND:Serum levels of resistin, an adipose tissue-derived adipokine, are increased in human obesity and are positively correlated with atheroscl...

journal_title：Journal of the American College of Cardiology

authors： Melone M,Wilsie L,Palyha O,Strack A,Rashid S

更新日期：2012-05-08 00:00:00

abstract：OBJECTIVES:The purpose of this study was to analyze the incidence of new atrial fibrillation or flutter (AFF) in the EMPHASIS-HF (Eplerenone in Mild Patients Hospitalization And SurvIval Study in Heart Failure) database. BACKGROUND:Aldosterone antagonism in heart failure might influence atrial fibrosis and remodeling ...

journal_title：Journal of the American College of Cardiology

authors： Swedberg K,Zannad F,McMurray JJ,Krum H,van Veldhuisen DJ,Shi H,Vincent J,Pitt B,EMPHASIS-HF Study Investigators.

更新日期：2012-05-01 00:00:00

abstract：:Until recently, vitamin K antagonists were the only available oral anticoagulants, but with numerous limitations that prompted the introduction of new oral anticoagulants targeting the single coagulation enzymes thrombin (dabigatran) or factor Xa (apixaban, rivaroxaban, and edoxaban) and given in fixed doses without c...

journal_title：Journal of the American College of Cardiology

authors： De Caterina R,Husted S,Wallentin L,Andreotti F,Arnesen H,Bachmann F,Baigent C,Huber K,Jespersen J,Kristensen SD,Lip GY,Morais J,Rasmussen LH,Siegbahn A,Verheugt FW,Weitz JI,Coordinating Committee.

更新日期：2012-04-17 00:00:00

abstract：OBJECTIVES:The objective of this study was to compare the cerebral embolic load of filter-protected versus proximal balloon-protected carotid artery stenting (CAS). BACKGROUND:Randomized trials comparing filter-protected CAS with carotid endarterectomy revealed a higher periprocedural stroke rate after CAS. Proximal b...

journal_title：Journal of the American College of Cardiology

authors： Bijuklic K,Wandler A,Hazizi F,Schofer J

更新日期：2012-04-10 00:00:00

abstract：OBJECTIVES:The purpose of this study was to characterize patients with mitral regurgitation (MR) and atrial fibrillation (AF) treated percutaneously using the MitraClip device (Abbott Vascular, Abbott Park, Illinois) and compare the results with surgery in this population. BACKGROUND:The EVEREST II (Endovascular Valve...

journal_title：Journal of the American College of Cardiology

authors： Herrmann HC,Gertz ZM,Silvestry FE,Wiegers SE,Woo YJ,Hermiller J,Segar D,Heimansohn D,Gray W,Homma S,Argenziano M,Wang A,Jollis J,Lampert MB,Alexander J,Mauri L,Foster E,Glower D,Feldman T

更新日期：2012-04-03 00:00:00

abstract：OBJECTIVES:This study sought to assess the diagnostic value of optical coherence tomography (OCT) in patients with suspected spontaneous coronary artery dissection (SCAD). BACKGROUND:SCAD is a rare but challenging clinical entity. METHODS:Following a prospective protocol, OCT was performed in 17 consecutive patients ...

journal_title：Journal of the American College of Cardiology

authors： Alfonso F,Paulo M,Gonzalo N,Dutary J,Jimenez-Quevedo P,Lennie V,Escaned J,Bañuelos C,Hernandez R,Macaya C

更新日期：2012-03-20 00:00:00

abstract：OBJECTIVES:The purpose of this study was to determine the prevalence, clinical characteristics, and management of coronary chronic total occlusions (CTOs) in current practice. BACKGROUND:There is little evidence in contemporary literature concerning the prevalence, clinical characteristics, and treatment decisions reg...

journal_title：Journal of the American College of Cardiology

authors： Fefer P,Knudtson ML,Cheema AN,Galbraith PD,Osherov AB,Yalonetsky S,Gannot S,Samuel M,Weisbrod M,Bierstone D,Sparkes JD,Wright GA,Strauss BH

更新日期：2012-03-13 00:00:00

abstract：OBJECTIVES:This study sought to assess percutaneous coronary intervention (PCI) for unprotected left main coronary artery (ULMCA) stenosis in routine U.S. clinical practice. BACKGROUND:Percutaneous coronary intervention for ULMCA stenosis is controversial; however, current use and outcomes of ULMCA PCI in routine U.S....

journal_title：Journal of the American College of Cardiology

authors： Brennan JM,Dai D,Patel MR,Rao SV,Armstrong EJ,Messenger JC,Curtis JP,Shunk KA,Anstrom KJ,Eisenstein EL,Weintraub WS,Peterson ED,Douglas PS,Hillegass WB

更新日期：2012-02-14 00:00:00

abstract：OBJECTIVES:The purpose of this study was to clarify the impact of sex-related differences in transcatheter aortic valve implantation (TAVI) for high-risk patients with severe aortic stenosis. BACKGROUND:Although TAVI is becoming a mature technique, the impact of sex differences remains unclear. METHODS:The TAVI patie...

journal_title：Journal of the American College of Cardiology

authors： Hayashida K,Morice MC,Chevalier B,Hovasse T,Romano M,Garot P,Farge A,Donzeau-Gouge P,Bouvier E,Cormier B,Lefèvre T

更新日期：2012-02-07 00:00:00

abstract：OBJECTIVES:The goal of this study was to examine the progression of central arterial pulse pressure (cPP) in women and the degree to which this can be reversed by nitrovasodilation. BACKGROUND:cPP can be partitioned into height of the first systolic shoulder (P1), generated by a forward pressure wave and related to ar...

journal_title：Journal of the American College of Cardiology

authors： Cecelja M,Jiang B,Spector TD,Chowienczyk P

更新日期：2012-01-31 00:00:00

abstract：OBJECTIVES:The purpose of this study was to assess the impact of patient population characteristics on accuracy by computed tomography angiography (CTA) to detect obstructive coronary artery disease (CAD). BACKGROUND:The ability of CTA to exclude obstructive CAD in patients of different pre-test probabilities and in p...

journal_title：Journal of the American College of Cardiology

authors： Arbab-Zadeh A,Miller JM,Rochitte CE,Dewey M,Niinuma H,Gottlieb I,Paul N,Clouse ME,Shapiro EP,Hoe J,Lardo AC,Bush DE,de Roos A,Cox C,Brinker J,Lima JA

更新日期：2012-01-24 00:00:00

abstract：OBJECTIVES:This study aimed to determine the diagnostic and prognostic value of urinary biomarkers of intrinsic acute kidney injury (AKI) when patients were triaged in the emergency department. BACKGROUND:Intrinsic AKI is associated with nephron injury and results in poor clinical outcomes. Several urinary biomarkers ...

journal_title：Journal of the American College of Cardiology

authors： Nickolas TL,Schmidt-Ott KM,Canetta P,Forster C,Singer E,Sise M,Elger A,Maarouf O,Sola-Del Valle DA,O'Rourke M,Sherman E,Lee P,Geara A,Imus P,Guddati A,Polland A,Rahman W,Elitok S,Malik N,Giglio J,El-Sayegh S,Dev

更新日期：2012-01-17 00:00:00

abstract：OBJECTIVES:The aim of this study was to explore post-myocardial infarction (MI) myocardial inflammation. BACKGROUND:Innate immune cells are centrally involved in infarct healing and are emerging therapeutic targets in cardiovascular disease; however, clinical tools to assess their presence in tissue are scarce. Furthe...

journal_title：Journal of the American College of Cardiology

authors： Lee WW,Marinelli B,van der Laan AM,Sena BF,Gorbatov R,Leuschner F,Dutta P,Iwamoto Y,Ueno T,Begieneman MP,Niessen HW,Piek JJ,Vinegoni C,Pittet MJ,Swirski FK,Tawakol A,Di Carli M,Weissleder R,Nahrendorf M

更新日期：2012-01-10 00:00:00

abstract：:In the recent era, no congenital heart defect has undergone a more dramatic change in diagnostic approach, management, and outcomes than hypoplastic left heart syndrome (HLHS). During this time, survival to the age of 5 years (including Fontan) has ranged from 50% to 69%, but current expectations are that 70% of newbo...

journal_title：Journal of the American College of Cardiology

authors： Feinstein JA,Benson DW,Dubin AM,Cohen MS,Maxey DM,Mahle WT,Pahl E,Villafañe J,Bhatt AB,Peng LF,Johnson BA,Marsden AL,Daniels CJ,Rudd NA,Caldarone CA,Mussatto KA,Morales DL,Ivy DD,Gaynor JW,Tweddell JS,Deal BJ,Fu

更新日期：2012-01-03 00:00:00

abstract：OBJECTIVES:The purpose of this study was to evaluate the role of the myocardial redox state in the development of in-hospital complications after cardiac surgery and the effect of statins on the myocardial redox state. BACKGROUND:Statins improve clinical outcome after cardiac surgery, but it is unclear whether they ex...

journal_title：Journal of the American College of Cardiology

authors： Antoniades C,Demosthenous M,Reilly S,Margaritis M,Zhang MH,Antonopoulos A,Marinou K,Nahar K,Jayaram R,Tousoulis D,Bakogiannis C,Sayeed R,Triantafyllou C,Koumallos N,Psarros C,Miliou A,Stefanadis C,Channon KM,Casadei B

更新日期：2012-01-03 00:00:00

abstract：OBJECTIVES:The aim of this study was to assess the impact of extreme (class III) obesity (body mass index [BMI] ≥40 kg/m(2)) on care and outcomes in patients with ST-segment elevation myocardial infarction (STEMI). BACKGROUND:Although its prevalence is increasing rapidly, little is known about the impact of extreme ob...

journal_title：Journal of the American College of Cardiology

authors： Das SR,Alexander KP,Chen AY,Powell-Wiley TM,Diercks DB,Peterson ED,Roe MT,de Lemos JA

更新日期：2011-12-13 00:00:00

abstract：OBJECTIVES:The aim of this study was to assess the efficacy of radiofrequency catheter ablation (RFCA) in the treatment of hypertrophic obstructive cardiomyopathy in children. BACKGROUND:Hypertrophic obstructive cardiomyopathy is an uncommon cause of left ventricular outflow tract obstruction in children. In symptomat...

journal_title：Journal of the American College of Cardiology

authors： Sreeram N,Emmel M,de Giovanni JV

更新日期：2011-12-06 00:00:00

abstract：OBJECTIVES:The purpose of this study is to demonstrate the technical success of carotid artery stenting in acute extracranial internal carotid artery (ICA) occlusion as well as the benefit in clinical outcome. BACKGROUND:Stroke caused by acute occlusion of the ICA is associated with a significant level of morbidity an...

journal_title：Journal of the American College of Cardiology

authors： Papanagiotou P,Roth C,Walter S,Behnke S,Grunwald IQ,Viera J,Politi M,Körner H,Kostopoulos P,Haass A,Fassbender K,Reith W

更新日期：2011-11-29 00:00:00

abstract：OBJECTIVES:The purpose of the study is to identify the predictors of clinical outcome (mortality and survival without repeat septal reduction procedures) of alcohol septal ablation for the treatment of patients with hypertrophic obstructive cardiomyopathy. BACKGROUND:Alcohol septal ablation is used for treatment of me...

journal_title：Journal of the American College of Cardiology

authors： Nagueh SF,Groves BM,Schwartz L,Smith KM,Wang A,Bach RG,Nielsen C,Leya F,Buergler JM,Rowe SK,Woo A,Maldonado YM,Spencer WH 3rd

更新日期：2011-11-22 00:00:00

abstract：OBJECTIVES:The aim of this study was to assess the role of transcatheter aortic valve implantation (TAVI) compared with medical treatment (MT) and surgical aortic valve replacement (SAVR) in patients with severe aortic stenosis (AS) at increased surgical risk. BACKGROUND:Elderly patients with comorbidities are at cons...

journal_title：Journal of the American College of Cardiology

authors： Wenaweser P,Pilgrim T,Kadner A,Huber C,Stortecky S,Buellesfeld L,Khattab AA,Meuli F,Roth N,Eberle B,Erdös G,Brinks H,Kalesan B,Meier B,Jüni P,Carrel T,Windecker S

更新日期：2011-11-15 00:00:00

abstract：OBJECTIVES:The objective was to define the characteristics of a real-world patient population treated with transcatheter aortic valve implantation (TAVI), regardless of technology or access route, and to evaluate their clinical outcome over the mid to long term. BACKGROUND:Although a substantial body of data exists in...

journal_title：Journal of the American College of Cardiology

authors： Moat NE,Ludman P,de Belder MA,Bridgewater B,Cunningham AD,Young CP,Thomas M,Kovac J,Spyt T,MacCarthy PA,Wendler O,Hildick-Smith D,Davies SW,Trivedi U,Blackman DJ,Levy RD,Brecker SJ,Baumbach A,Daniel T,Gray H,Mulle

更新日期：2011-11-08 00:00:00

abstract：OBJECTIVES:The aim of this study was to investigate the effect of renin-angiotensin system blockade on outcomes in patients with aortic regurgitation (AR). BACKGROUND:Angiotensin-converting enzyme (ACE) inhibitors have the potential to reduce afterload, blunt left ventricular wall stress, and limit left ventricular di...

journal_title：Journal of the American College of Cardiology

authors： Elder DH,Wei L,Szwejkowski BR,Libianto R,Nadir A,Pauriah M,Rekhraj S,Lim TK,George J,Doney A,Pringle SD,Choy AM,Struthers AD,Lang CC

更新日期：2011-11-08 00:00:00

abstract：OBJECTIVES:We investigated whether statin therapy could be beneficial in patients with acute myocardial infarction (AMI) who have baseline low-density lipoprotein cholesterol (LDL-C) levels below 70 mg/dl. BACKGROUND:Intensive lipid-lowering therapy with a target LDL-C value <70 mg/dl is recommended in patients with v...

journal_title：Journal of the American College of Cardiology

authors： Lee KH,Jeong MH,Kim HM,Ahn Y,Kim JH,Chae SC,Kim YJ,Hur SH,Seong IW,Hong TJ,Choi DH,Cho MC,Kim CJ,Seung KB,Chung WS,Jang YS,Rha SW,Bae JH,Cho JG,Park SJ,KAMIR (Korea Acute Myocardial Infarction Registry) Investigat

更新日期：2011-10-11 00:00:00

abstract：OBJECTIVES:The aim of this study was to analyze the relationship between payment source and quality of care and outcomes in heart failure (HF). BACKGROUND:HF is a major cause of morbidity and mortality. There is a lack of studies assessing the association of payment source with HF quality of care and outcomes. METHOD...

journal_title：Journal of the American College of Cardiology

authors： Kapoor JR,Kapoor R,Hellkamp AS,Hernandez AF,Heidenreich PA,Fonarow GC

更新日期：2011-09-27 00:00:00

abstract：OBJECTIVES:The aim of this study was to compare the 3-year efficacy and safety of biodegradable polymer with permanent polymer stents and of everolimus-eluting stents (EES) with sirolimus-eluting stents (SES). BACKGROUND:Biodegradable polymer drug-eluting stents (DES) offer potential for enhanced late outcomes in comp...

journal_title：Journal of the American College of Cardiology

authors： Byrne RA,Kastrati A,Massberg S,Wieczorek A,Laugwitz KL,Hadamitzky M,Schulz S,Pache J,Fusaro M,Hausleiter J,Schömig A,Mehilli J,ISAR-TEST 4 Investigators.

更新日期：2011-09-20 00:00:00

abstract：OBJECTIVES:The purpose of this study was to define the incidence and characterization of cardiovascular cause of sudden death in the young. BACKGROUND:The epidemiology of sudden cardiac death (SCD) in young adults is based on small studies and uncontrolled observations. Identifying causes of sudden death in this popul...

journal_title：Journal of the American College of Cardiology

authors： Eckart RE,Shry EA,Burke AP,McNear JA,Appel DA,Castillo-Rojas LM,Avedissian L,Pearse LA,Potter RN,Tremaine L,Gentlesk PJ,Huffer L,Reich SS,Stevenson WG,Department of Defense Cardiovascular Death Registry Group.

更新日期：2011-09-13 00:00:00

abstract：OBJECTIVES:We evaluated the relationship between acute hemodynamic response (AHR) and reverse remodeling (RR) in cardiac resynchronization therapy (CRT). BACKGROUND:CRT reduces mortality and morbidity in heart failure patients; however, up to 30% of patients do not derive symptomatic benefit. Higher proportions do not...

journal_title：Journal of the American College of Cardiology

authors： Duckett SG,Ginks M,Shetty AK,Bostock J,Gill JS,Hamid S,Kapetanakis S,Cunliffe E,Razavi R,Carr-White G,Rinaldi CA

更新日期：2011-09-06 00:00:00